CaptureSelect™ AAT-XL Affinity Matrix

CaptureSelect™ AAT-XL Affinity Matrix

CaptureSelect™ AAT-XL Affinity Matrix is specifically designed for the purification of native human alpha-1 antitrypsin (AAT) from complex biological sources such as plasma and serum, as well as recombinant human AAT from cell culture supernatants. With its high selectivity and mild elution conditions at pH 6, this affinity matrix enables efficient, one-step purification with excellent yield and purity.

Key Features:

• Highly Selective – Optimized for both native and recombinant human AAT.

• High Yield & Recovery – Achieves excellent purity in a single purification step.

• Mild Elution Conditions – Elutes at pH 6, minimizing potential protein degradation.

• Scalable – Suitable for small- and large-scale purification processes.

• Animal-Origin Free – Manufactured using recombinant VHH affinity ligands expressed in Saccharomyces cerevisiae, ensuring a completely non-animal-derived process.

Specifications:

• Binding Capacity: 15 mg AAT/mL resin

• Flow Rate: 50 to 200 cm/hr (up to 2 bar)

• Matrix: Agarose-based, epoxide-activated

• Particle Size: 65 ± 10 μm

• Form: Resin Slurry

• Product Line: CaptureSelect™

• Quantity: 50 mL

• Type: Affinity Matrix

• Ligand Type: AAT-XL affinity ligand

• Unit Size: Each

Elution Conditions:

• Buffer: 20 mM Tris, 2.0 M MgCl₂, pH 6.0

Storage & Stability:

• Formulation Buffer: 20% (v/v) ethanol

• Storage Conditions: Store at 2°C to 8°C

Applications:

This affinity matrix is ideal for researchers purifying human alpha-1 antitrypsin from plasma, serum, or recombinant sources. Its high specificity and mild elution conditions make it particularly suitable for sensitive proteins.

For Research Use Only. 

Volume: 50 mL

Catalog number 2943832050

Expiration date: 08/08/2026