Stirred-Tank Bioreactors

Stirred-tank bioreactors (STRs) are the industry standard for scalable cell cultivation and microbial fermentation, widely used in biopharmaceutical manufacturing, protein production, enzyme expression, and industrial biotechnology. These versatile systems are engineered to support batch, fed-batch, and continuous bioprocessing modes, offering exceptional control over key culture parameters and enabling reproducible, high-yield production of biologics at laboratory, pilot, and commercial scales. STRs are typically constructed from stainless steel or borosilicate glass, providing robust, sterilizable environments for cultivating a wide range of organisms, including mammalian cells, CHO cells, yeast, E. coli, fungi, and insect cells. Their modular design includes mechanical or magnetic agitators, which ensure uniform mixing and mass transfer for effective nutrient distribution, oxygen delivery, and waste removal. STRs also incorporate advanced control systems for regulating temperature, pH, dissolved oxygen (DO), agitation speed, and gas flow, ensuring optimal growth conditions for various cell lines and microbial cultures. These bioreactors are essential in recombinant protein production, monoclonal antibody (mAb) expression, vaccine development, and biofuel or enzyme synthesis. They are compatible with a broad range of upstream and downstream processing workflows and often integrate with real-time monitoring tools such as pH/DO probes, Raman sensors, and PAT systems for enhanced process insight and automation. Stirred-tank bioreactors are also widely adopted in Good Manufacturing Practice (GMP) environments due to their proven scalability, clean-in-place (CIP) and steam-in-place (SIP) capabilities, and long operational life. With customizable vessel sizes and configurable ports, they adapt to a variety of process development and manufacturing needs. At Wasteless Bio, we offer a curated selection of refurbished and surplus stirred-tank bioreactors from top-tier manufacturers. Each listing includes comprehensive specifications such as vessel volume, agitation method, control systems, sterilization compatibility, and application suitability. Sourcing STRs through Wasteless Bio allows facilities to reduce capital expenditure while promoting sustainable, high-performance bioprocessing through equipment reuse.