Gaskets
Gaskets are essential sealing components in bioprocessing systems, used to create secure, leak-proof connections between equipment such as bioreactors, fermenters, filters, tubing assemblies, and single-use manifolds. Designed to maintain sterility and mechanical integrity in both stainless steel and single-use systems, gaskets play a critical role in ensuring process reliability, preventing fluid loss, and reducing the risk of contamination in biopharmaceutical manufacturing, cell therapy production, vaccine development, and industrial biotechnology applications.
These sealing solutions are available in a wide range of materials, sizes, and configurations, with compatibility tailored to specific applications and operating conditions. Common gasket materials include EPDM (ethylene propylene diene monomer), silicone, PTFE (polytetrafluoroethylene), FKM (Viton®), and platinum-cured elastomers, all selected for their chemical resistance, thermal stability, flexibility, and biocompatibility. For single-use systems, gaskets may be integrated into pre-sterilized assemblies or manifolds, while in stainless steel process lines, they are typically used in Tri-Clamp or sanitary fittings to provide secure, sterile connections.
In bioprocessing workflows, gaskets must withstand a range of stresses—including pressure fluctuations, temperature variations, repeated steam-in-place (SIP) or clean-in-place (CIP) cycles, and exposure to aggressive cleaning agents or solvents. High-quality gaskets help prevent leaks during media transfers, filtration steps, sampling, or harvest operations, and are crucial to maintaining system integrity during prolonged runs or scale-up processes.
Proper gasket selection is essential for maintaining compliance with GMP, USP Class VI, ISO 10993, and other regulatory standards. Gaskets used in direct contact with process fluids must meet strict extractables and leachables criteria to avoid compromising product purity or safety.
At Wasteless Bio, we offer a variety of surplus and new gaskets from leading bioprocessing suppliers. Each listing includes specifications such as material type, inner/outer diameter, temperature range, pressure rating, and regulatory compliance. By sourcing gaskets through Wasteless Bio, labs and manufacturers can ensure leak-free, sterile operation while reducing procurement costs and supporting sustainable equipment reuse in modern biomanufacturing environments.
Gaskets are essential sealing components in bioprocessing systems, used to create secure, leak-proof connections between equipment such as bioreactors, fermenters, filters, tubing assemblies, and single-use manifolds.
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