pH, DO, Raman probes

pH, dissolved oxygen (DO), and Raman probes are essential analytical sensors used for real-time monitoring and control of bioprocess conditions in bioreactors, fermenters, and other cell culture systems. These advanced instruments provide critical data on the physiological environment within bioprocess vessels, enabling researchers and production teams to maintain optimal conditions for cell viability, growth, and product yield. Whether used in biopharmaceutical manufacturing, cell therapy development, microbial fermentation, or vaccine production, these probes support greater process insight, automation, and regulatory compliance. pH probes continuously measure the acidity or alkalinity of the culture medium, a key parameter that influences enzyme activity, nutrient availability, and cellular metabolism. Accurate pH control helps maintain stable environments for mammalian, bacterial, yeast, and insect cells, preventing process deviations that could affect product quality. DO probes track the concentration of dissolved oxygen in the culture medium—vital for aerobic processes where oxygen availability impacts cell growth and productivity. These sensors allow for dynamic adjustments to gas flow, agitation speed, and nutrient feeds in batch, fed-batch, or perfusion systems, helping optimize oxygen transfer rates. Raman probes are advanced, non-invasive optical sensors that offer real-time spectral analysis of key metabolites, nutrients, and cell densities. Used in conjunction with Process Analytical Technology (PAT) frameworks, Raman spectroscopy enables predictive process control, supporting QbD (Quality by Design) initiatives and reducing the need for offline sampling. Modern probes are available in reusable and single-use formats, with gamma-stable options for integration into disposable bioreactor bags. Many are pre-calibrated, autoclavable, or compatible with clean-in-place (CIP) systems, ensuring compatibility with GMP-compliant manufacturing. At Wasteless Bio, we offer surplus and refurbished pH, DO, and Raman probes from trusted brands. Each listing includes specifications such as measurement range, compatibility, sterility, calibration method, and output integration. By sourcing process monitoring probes through Wasteless Bio, labs gain reliable control solutions while reducing procurement costs and promoting sustainable, data-driven bioprocessing.