Microtome

Microtomes are precision sectioning instruments used to cut extremely thin tissue slices from fixed and embedded samples for microscopic examination. These slices, often between 2 and 10 microns thick, are used in histopathology, immunohistochemistry (IHC), molecular diagnostics, and academic research. Microtomes play a central role in preparing specimens for staining and microscopic imaging, making them a critical tool in understanding tissue architecture and disease pathology. There are several types of microtomes available: rotary microtomes for routine histology, sliding microtomes for larger tissues like brain or lung, and ultramicrotomes for ultra-thin sections in electron microscopy. Most modern rotary microtomes feature manual or motorized sectioning, adjustable cutting thickness, specimen orientation controls, and anti-roll plates to maintain section integrity. Microtomes are commonly used in preparing formalin-fixed paraffin-embedded (FFPE) tissue blocks. The resulting sections are stained with dyes such as H&E (hematoxylin and eosin) or subjected to advanced techniques like IHC and in situ hybridization (ISH) to reveal cellular structures, protein localization, and genetic markers. This enables researchers and pathologists to study cancer progression, inflammation, tissue regeneration, and more. Some models come with disposable or reusable blade holders, section waste trays, and ergonomic handwheels for safe, accurate, and fatigue-free operation. More advanced systems include touchscreen interfaces, automated trimming cycles, and integrated memory functions for high-throughput workflows. At Wasteless Bio, we offer affordable, surplus microtomes from leading manufacturers. Each listing includes specs such as section thickness range, motorization, sample orientation capabilities, and blade compatibility. Buying through Wasteless Bio supports cost-effective research while reducing waste through the reuse of precision instruments.