LC-MS (Liquid Chromatography-Mass Spectrometry)

LC-MS (Liquid Chromatography-Mass Spectrometry) is a highly versatile and sensitive analytical technique that combines the separation capabilities of liquid chromatography (LC) with the detection precision of mass spectrometry (MS). LC-MS systems are fundamental tools in biomedical research, pharmaceutical development, metabolomics, proteomics, and clinical diagnostics due to their ability to identify and quantify complex biological and chemical mixtures. In LC-MS workflows, samples are first separated by their chemical or physical properties using high-performance liquid chromatography (HPLC). The eluted compounds are then introduced into the mass spectrometer, where they are ionized and sorted based on their mass-to-charge ratio (m/z). This dual-stage process provides both quantitative and qualitative data, enabling the identification of thousands of compounds in a single run. LC-MS is widely used for protein characterization, including peptide mapping, post-translational modification analysis, and biomarker discovery. In pharmacokinetics and drug metabolism studies (PK/ADME), LC-MS enables precise monitoring of drug absorption, distribution, metabolism, and excretion in biological matrices. It’s also used in small molecule profiling, metabolite quantification, food contamination screening, and clinical biomarker validation. Modern LC-MS systems may include triple quadrupole (QQQ), time-of-flight (TOF), or Orbitrap detectors, offering varying levels of sensitivity, resolution, and speed. Many instruments are paired with autosamplers, UHPLC modules, and data analysis software to streamline workflows and ensure reproducibility. At Wasteless Bio, we offer access to high-performance, surplus LC-MS systems at significantly reduced costs. Each listing includes key specifications such as ion source type (ESI, APCI), mass analyzer configuration, mass range, resolution, detection limit, and software compatibility. Sourcing through Wasteless Bio allows labs to stay on the cutting edge of analytical science while promoting sustainability through the reuse of world-class instrumentation.