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Product Details
- Manufacturer
- Invitrogen
- SKU
- 11337043
- Shipped From
- United Kingdom
About this product
GAD67 Polyclonal Antibody, Invitrogen™ (Goat Polyclonal Antibody)
Product Overview:
- Host: Goat
- Type: Polyclonal, unconjugated
- Target: GAD67 (Glutamate decarboxylase 1, GAD1), 67 kDa isoform
- Immunogen: Synthetic peptide sequence (PDSPQRREKLHK) from internal region of human GAD1
- Tested Reactivity: Human; predicted to react with bovine, canine, mouse, porcine, and rat based on sequence homology
- Applications: Flow cytometry, immunocytochemistry, Western blot
- Concentration: 0.5 mg/mL
- Formulation: Liquid in TBS with 0.5% BSA and 0.02% sodium azide, pH 7.3
- Storage: -20°C, avoid freeze/thaw cycles
- Quantity:100 μg
- Purification: Ammonium sulfate precipitation
- Research Use: For research use only (RUO)
Key Biological Context:
- GAD67 and GAD65 are enzymes that catalyze the conversion of L-glutamic acid to GABA (gamma-aminobutyric acid), a major inhibitory neurotransmitter in the brain.
- GAD67 is distributed throughout the cell and responsible for basal GABA synthesis, while GAD65 is associated with synaptic vesicle membranes and is recruited during increased neurotransmission demand.
- Loss of GAD67 is lethal, while loss of GAD65 impairs GABA neurotransmission.
- Alternative splicing produces two isoforms: the predominant GAD-67 and the minor GAD-25.
Product Identifiers:
- Catalog Number: PA519065
- UniProt ID: Q99259 (GAD1).
Storage and Handling: Store at -20°C; avoid repeated freeze/thaw cycles to maintain antibody integrity.
Intended Use: Suitable for detecting GAD67 in various species for research in neuroscience, neurochemistry, and related fields
Product Code: 11337043
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