Enzo Biochem Rp-8-Br-cGMPS-2
Overview
Rp-8-Br-cGMPS is a potent and metabolic-stable sulfur-modified analog of cyclic GMP. It functions as a lipophilic inhibitor of cGMP-dependent protein kinase (PKG), specifically targeting PKG type I and II by competing with cGMP for binding sites without activating the enzyme.
Highlights
- Highly lipophilic membrane-permeant properties for efficient cellular uptake.
- Increased metabolic stability against cyclic nucleotide phosphodiesterases (PDEs).
- Effective competitive inhibition of cGMP-dependent protein kinases I and II.
- Phosphorothioate modification ensures resistance to enzymatic degradation.
At-a-glance
- Capabilities
- Competitive inhibition of PKG I and PKG II; PDE resistance.
- Form
- Lyophilized solid
- Recommended Applications
- Signal transduction studies, vascular smooth muscle research, neurobiology, and ion channel modulation assays.
- Condition
- Surplus/second-hand; stored under manufacturer-recommended conditions.
Applications
Utilized in cardiovascular research to study nitric oxide and cGMP-mediated signaling pathways in smooth muscle cells. It is also applied in neuroscience to investigate the role of PKG in synaptic plasticity and long-term depression (LTD).
Sustainability
By rehoming surplus lab products, this listing supports waste reduction and resource efficiency.
Responsible use & safety
- Require training/authorization before use.
- Inspect before operation; do not use if safety features are compromised.
- Follow manufacturer's manual for operation and maintenance.
- Equipment-specific guidance (e.g., keep airflow clear, replace filters regularly, decontaminate after use).
