Sartobind® STIC PA Cassette

Sartobind STIC® PA Cassette, 0.8 L, 4 mm Bed Height – High-Salt Anion Exchange Membrane

Description

The Sartobind STIC® PA Cassette (0.8 L, 4 mm bed height) is a next-generation salt-tolerant interaction chromatography (STIC) device designed for high-capacity removal of process-related contaminants during monoclonal antibody (mAb) and biotherapeutic downstream processing. Engineered with a primary amine (PA) ligand on a regenerated macro-porous cellulose matrix, this membrane exhibits exceptional binding capacity in high-salt environments—eliminating the need for dilution after cation exchange (CEX) steps.

Optimized for flow-through anion exchange chromatography (AEX), the 0.8 L cassette integrates seamlessly into modular systems up to 100 L total membrane volume, offering a scalable, pod-like solution that combines disposable simplicity with column-like throughput. Ideal for host cell protein (HCP), DNA, endotoxin, and virus clearance, the STIC® PA cassette supports up to 30 bed volumes/min, accelerating process development without compromising yield or quality.

Key Features:

• 0.8 L membrane volume with 4 mm bed height for intermediate-scale bioproduction

• PA ligand chemistry delivers high binding capacity at up to 1.5 M NaCl

• Modular cassette design supports up to 100 L membrane volume

• High flow rate capability – up to 30 bed volumes/min

• Removes HCPs up to 10 kg/L membrane, DNA, endotoxins, and viruses

• Plug-and-play format simplifies integration and reduces validation effort

• Disposable after single use, reducing cross-contamination risk

• Ideal for use in mAb, vaccine, and recombinant protein purification workflows

Applications

• Monoclonal antibody (mAb) production

• Downstream purification of biopharmaceuticals

• High-throughput anion exchange for contaminant removal

• Vaccine manufacturing

• Virus and endotoxin clearance in flow-through processes

Specifications

• Product Name: Sartobind STIC® PA Cassette

• Volume: 0.8 L

• Bed Height: 4 mm

• Ligand Type: Primary Amine (PA)

• Matrix: Regenerated cross-linked cellulose

• Operating Mode: Flow-through

• Max Flow Rate: Up to 30 bed volumes/min

• Disposable: Yes

• Compatibility: Modular systems up to 100 L