Enzo Biochem 17-DMAG
Overview
17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin) is a semi-synthetic derivative of the antibiotic geldanamycin. It functions as a potent, water-soluble inhibitor of Heat Shock Protein 90 (Hsp90), exhibiting higher bioavailability and reduced hepatotoxicity compared to its parent compound.
Highlights
- Potent Hsp90 inhibition with high water solubility for versatile experimental buffer compatibility.
- Enhanced metabolic stability and lower toxicity profile than 17-AAG.
- Maintains high affinity for the ATP-binding pocket of Hsp90, disrupting the stabilization of oncogenic client proteins.
- Proven efficacy in modulating cellular stress response pathways in vitro.
At-a-glance
- CAS
- 467214-20-6
- Formula
- C32H48N4O8
- Molecular Weight
- 616.8 g/mol
- Purity
- ≥98% (HPLC)
- Form
- Lyophilized powder or solid
- Recommended Applications
- Cancer research, proteomics, heat shock protein mapping, cell signaling inhibition.
- Compatibility
- Soluble in water, DMSO, and ethanol.
- Storage Condition
- Store at -20°C; protect from light and moisture.
- Condition
- Surplus/second-hand; stored under manufacturer-recommended conditions. [Package Status: UNUSED_OR_SEALED.]
Applications
17-DMAG is utilized in oncology research to induce the degradation of Hsp90 client proteins such as HER2, Akt, and Raf-1. It is frequently applied in cell culture assays to study apoptosis induction and in signal transduction research to observe protein folding interference.
Sustainability
By rehoming surplus lab products, this listing supports waste reduction and resource efficiency.
Responsible use & safety
- Require training/authorization before use.
- Inspect before operation; do not use if safety features are compromised.
- Follow manufacturer's manual for operation and maintenance.
- Decontaminate surfaces and dispose of chemical waste according to local institutional protocols.
