TFF Systems (Tangential Flow Filtration)

TFF Systems (Tangential Flow Filtration) are essential tools in modern bioprocessing workflows, enabling efficient concentration, diafiltration, and buffer exchange of proteins, antibodies, and other biologics. Unlike traditional dead-end filtration, TFF systems operate by passing fluid tangentially across a membrane surface, reducing fouling and allowing for higher throughput and extended filter life. At Wasteless Bio, we provide a wide selection of surplus and repurposed TFF systems ideal for research, pilot-scale, and GMP-compliant commercial manufacturing environments. These membrane-based purification systems are especially valuable in the downstream processing of biologic drugs, where maintaining product integrity and maximizing recovery are top priorities. TFF systems are commonly used after cell harvest and clarification steps to concentrate product streams before chromatography, as well as in final formulation stages for buffer exchange. The versatility of TFF systems allows them to be adapted for various biotherapeutics, including monoclonal antibodies (mAbs), recombinant proteins, gene therapy vectors, and vaccines. Our TFF system listings include both manual and automated platforms, ranging from compact benchtop units for lab-scale processing to fully integrated skid-mounted systems for large-scale operations. These systems often include hollow fiber, flat sheet, or spiral-wound membrane modules, and support a wide range of molecular weight cut-offs (MWCOs) to accommodate specific separation needs. Brands frequently available on Wasteless Bio include industry leaders such as MilliporeSigma, Cytiva (GE Healthcare), Pall, and Sartorius. By sourcing high-quality, pre-owned TFF systems through Wasteless Bio, labs and biomanufacturers can significantly reduce equipment costs while aligning with sustainability and waste-reduction goals. Each listing provides detailed specifications, including membrane type, flow rate, and scalability, helping you select the right system for your process requirements. Whether you are concentrating harvest fluid, exchanging buffers before formulation, or purifying therapeutic proteins, our Tangential Flow Filtration systems offer a reliable and efficient solution for your downstream processing needs.